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| − | + | ==<span style="color:#000000">Abstract:</span> <span style="color:#009440">bio(t)</span><span style="color:#3070b3">INK</span> <span style="color:#8d8d8d">- rethINK tissue printing</span>== | |
| − | + | <!-- <div class="imagelink float-right">[[Media:Muc_Vortrag_001.png]][[Image:Muc_Vortrag_001.png|920px|link=]]</div> //--> | |
| − | + | We are living in an aging society that is facing a decreasing supply of donor organs for medical transplantation. To confront this pressing issue, we developed a game-changing approach to bioprint tissues for biomedical applications. Our interdisciplinary work aims to create a unique ink, named bio(t)INK, to revolutionize bioprinting. The printing process uses a [https://2016.igem.org/Team:LMU-TUM_Munich/Hardware hijacked 3D printer] and two components of biotINK to induce an instantaneous [https://2016.igem.org/Team:LMU-TUM_Munich/Proof polymerization reaction], creating three-dimensional multi-cellular structures in a user-definable manner. The principle of this two-component glue relies on the rapid and specific interaction of biotin and its tetrameric [https://2016.igem.org/Team:LMU-TUM_Munich/Proteins binding protein] avidin. To make use of this high biotin-avidin affinity for cell-cell cross-linking, we [https://2016.igem.org/Team:LMU-TUM_Munich/Receptors engineered cells presenting biotin moieties or biotin-binding proteins on their surfaces] as well as [https://2016.igem.org/Team:LMU-TUM_Munich/Proteins recombinant matrix proteins], which [https://2016.igem.org/Team:LMU-TUM_Munich/Proof co-polymerize upon printing]. Furthermore, we explored genetic circuits which allow us to functionalize the bio-synthetic tissue and install biosafety mechanisms. Altogether, we are confident that our system provides the necessary means to advance the SynBio community to the next level – the tissue level.<br> | |
| − | ==<span style="color:#000000">Abstract:</span> <span style="color:#009440"> | + | <div class="imagelink float-right">[[Media:Muc_Finalsphoto_001.png]][[Image:Muc_Finalsphoto_001.png|920px|link=]]</div> |
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=Sponsors= | =Sponsors= | ||
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<li class="sponsor">[[Image:Muc16_Sponsor_ChemieTUM.png|link=http://www.ch.tum.de/|alt=Department Chemie der TUM]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_ChemieTUM.png|link=http://www.ch.tum.de/|alt=Department Chemie der TUM]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_BioM.png|link=http://www.bio-m.org|alt=Bio M]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_BioM.png|link=http://www.bio-m.org|alt=Bio M]]</li> | ||
| + | <li class="sponsor">[[Image:Muc16_Sponsor_Biotechnikum.jpg|link=http://www.industrial-biotechnology.tum.de/technikum/|alt=Biotechnikum TUM]]</li> | ||
| + | <li class="sponsor">[[Image:Muc16_Sponsor_XLprotein.tif|link=http://xl-protein.com/|alt=XL protein]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_Promega.png|link=http://www.promega.de/|alt=Promega]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Promega.png|link=http://www.promega.de/|alt=Promega]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_IDT.png|link=http://www.idt-DNA.com|alt=Integrated DNA Technilogies]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_IDT.png|link=http://www.idt-DNA.com|alt=Integrated DNA Technilogies]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_Geneious.png|link=http://www.geneious.com|alt=geneious]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Geneious.png|link=http://www.geneious.com|alt=geneious]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_NEB.png|link=http://www.neb.com|alt=New England Biolabs]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_NEB.png|link=http://www.neb.com|alt=New England Biolabs]]</li> | ||
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<li class="sponsor">[[Image:Muc16_Sponsor_Eurofins.png|link=http://www.eurofinsgenomics.eu|alt=eurofins]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Eurofins.png|link=http://www.eurofinsgenomics.eu|alt=eurofins]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_Serva.png|link=http://www.serva.de/|alt=Serva]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Serva.png|link=http://www.serva.de/|alt=Serva]]</li> | ||
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<li class="sponsor">[[Image:Muc16_Sponsor_Zymo-Research.png|link=http://www.zymoresearch.com/|alt=Zymo Research]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Zymo-Research.png|link=http://www.zymoresearch.com/|alt=Zymo Research]]</li> | ||
<li class="sponsor">[[Image:Muc16_Sponsor_Qiagen.png|link=http://www.qiagen.com/|alt=Quiagen]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Qiagen.png|link=http://www.qiagen.com/|alt=Quiagen]]</li> | ||
| + | <li class="sponsor">[[Image:Muc16_Sponsor_CarlRoth.png|link=http://www.carlroth.com|alt=Carl Roth]]</li> | ||
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<li class="sponsor">[[Image:Muc16_Sponsor_Faust.jpeg|link=http://www.faustlabscience.de/|alt=Faust]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Faust.jpeg|link=http://www.faustlabscience.de/|alt=Faust]]</li> | ||
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<li class="sponsor">[[Image:Muc16_Sponsor_Satorius.jpeg|link=http://www.sartorius.de|alt=Sartorius]]</li> | <li class="sponsor">[[Image:Muc16_Sponsor_Satorius.jpeg|link=http://www.sartorius.de|alt=Sartorius]]</li> | ||
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Latest revision as of 17:13, 22 December 2016
Abstract: bio(t)INK - rethINK tissue printing
We are living in an aging society that is facing a decreasing supply of donor organs for medical transplantation. To confront this pressing issue, we developed a game-changing approach to bioprint tissues for biomedical applications. Our interdisciplinary work aims to create a unique ink, named bio(t)INK, to revolutionize bioprinting. The printing process uses a hijacked 3D printer and two components of biotINK to induce an instantaneous polymerization reaction, creating three-dimensional multi-cellular structures in a user-definable manner. The principle of this two-component glue relies on the rapid and specific interaction of biotin and its tetrameric binding protein avidin. To make use of this high biotin-avidin affinity for cell-cell cross-linking, we engineered cells presenting biotin moieties or biotin-binding proteins on their surfaces as well as recombinant matrix proteins, which co-polymerize upon printing. Furthermore, we explored genetic circuits which allow us to functionalize the bio-synthetic tissue and install biosafety mechanisms. Altogether, we are confident that our system provides the necessary means to advance the SynBio community to the next level – the tissue level.
Sponsors
