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==<span style="color:#000000">Abstract:</span> <span style="color:#009440">biot</span><span style="color:#3070b3">INK</span> <span style="color:#8d8d8d">- rethINK tissue printing</span>== | ==<span style="color:#000000">Abstract:</span> <span style="color:#009440">biot</span><span style="color:#3070b3">INK</span> <span style="color:#8d8d8d">- rethINK tissue printing</span>== |
Revision as of 20:39, 27 November 2016
![Muc16 Team Slider5.jpeg](/wiki/images/1/1a/Muc16_Team_Slider5.jpeg)
Abstract: biotINK - rethINK tissue printing
We are living in an aging society that is facing a decreasing supply of donor organs. To confront this pressing issue, we developed a game-changing approach to bioprint tissues for biomedical applications. Our interdisciplinary work aims to create a unique ink, named biotINK, to revolutionize bioprinting. The printing process uses a hijacked 3D printer and two components of biotINK to induce an instantaneous polymerization reaction, creating three-dimensional multi-cellular structures in a user-definable manner. The principle of this two-component glue relies on the rapid and specific interaction of biotin and its tetrameric binding protein avidin. To make use of this high biotin-avidin affinity for cell-cell cross-linking, we engineered cells presenting biotin moieties or biotin-binding proteins on their surfaces as well as recombinant matrix proteins, which co-polymerize upon printing. Furthermore, we explored different genetic circuits which allow us to functionalize the bio-synthetic tissue and install biosafety mechanisms.
Altogether, we are confident that our system provides the necessary means to advance the SynBio community to the next level – the tissue level.
Sponsors
![](http://www.clustrmaps.com/map_v2.png?u=mRta&d=_y__2DJND-ZNlbMa3B1CYmXwre4LhtEKR8bxIgLw3A8)