Team:LMU-TUM Munich/Entrepreneurship
still missing: 2x citation from companies
Due to non-disclosure agreements company names were made anonymous and taken out of the appendix. Our Business model is applied in the drug development process within the pharmaceutical industry.
1 Executive Summary
3D printing is currently revolutionizing many industries as well as the biotech sector. We build on this trend in order to bring our revolutionary technology to the market. To this end, we genetically engineer cells to make them produce a "glue" that connects these cells within milliseconds in order to build stable and living tissues by 3D printing.
We aim to introduce this technology to the pharmaceutical industry. Drugs are developed over a span of 10 years, and the whole process costs up to $ 3 billion. Both these factors stem from the lack of appropriate testing systems for drug candidates. Our printed tissues should be applied subsequent to 2D cell culture screening and before animal testing in order to identify promising drug candidates at an early stage and thus solve the customer's problem of cost and time in drug development.
In our business model, we print liver tissue into a 96-well plate and provide it to our customers from the pharmaceutical industry for toxicity studies in the context of drug development. These pieces of tissue constitute customized “mini-organs” for specific drug testing. For the first time, our technology allows us to achieve a quality of printed tissue that enables our customers to use these tissues in the drug development process, which corresponds to our USP. Thus, we enable our customers to develop drugs faster, with lower opportunity costs and less animal testing. We expect annual sales of 400–500 panels for a single strategic partner within the first year. Based on our interviews, a price of € 10,000 per plate is adequate, corresponding to a turnover of € 4–5 million with a gross profit margin of about 97% without taking further investment costs for business development into account.
Within the total market for cell-based drug development, our target market is located in cells and tissues. This target market exhibits a total market volume of $ 100 million today and will grow to $ 300 million by 2019. Based on our interview, company B would be the first potential customer as soon as the results have been scientifically validated.
The competition is heterogeneous. Numerous indirect competitors act in the field of drug development by providing their customers with e.g. 2D cell cultures. Direct competitors are exclusively linked to the 3D cell culture area. Among these direct competitors, we consider Organovo to be our closest rival. Organovo also produces 3D bioprinting products for the pharmaceutical industry, but based on a significantly less powerful technology. Our printed tissues stand out by a significantly higher accuracy, stability and flexibility compared to competitors. In cooperation with the Technical University of Munich, a patent application is currently being considered.
We are seeking for an initial investment to overcome the high financial barrier that hinders market entry. Furthermore, we are interested in a network to acquire pilot customers and in an investor who is experienced in regulatory hurdles when entering the market in the pharmaceutical industry.�
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Links
Wikiinterner Link Team:LMU-TUM_Munich/Materials (As described in the Materials section)
Wikiexterner Link Visit W3Schools
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Bilder
Introduction
Design
Experiments
Proof of concept
Demonstrate
Discussion
References
- ↑ Schmidt, T. G., & Skerra, A. (2007). The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins. Nature protocols, 2(6), 1528-1535.
